Quick Reference
- Scientific Rating
-
5.0/ 5.0
- Standardized Form
- L-5-Methyltetrahydrofolate (5-MTHF)
Folate is critical for one-carbon metabolism and DNA methylation. While synthetic folic acid requires enzymatic conversion by the MTHFR enzyme, the active form, L-5-Methyltetrahydrofolate (5-MTHF), bypasses this genetic bottleneck, making it highly bioavailable and critical for preventing neural tube defects and managing homocysteine.
Table of Contents
Clinical Summary
Gold-standard nutrient in prenatal care and for cardiovascular/cognitive health via homocysteine reduction.
Dosage Guidelines
400mcg DFE daily; 600mcg during pregnancy.
Safety & Side Effects
Generally safe. High doses of synthetic folic acid (not 5-MTHF) can mask a B12 deficiency.
Known Interactions
Methotrexate acts as a folate antagonist.
Scientific References
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Medical Disclaimer
The information provided in this clinical review is for educational and informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment.
*These statements have not been evaluated by the Food and Drug Administration (FDA). This product or ingredient is not intended to diagnose, treat, cure, or prevent any disease.
Always consult your physician or other qualified health provider with any questions you may have regarding a medical condition, or before beginning any new diet, fitness, supplement, or treatment regimen, especially if you have pre-existing medical conditions or are taking prescribed medications.
