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HFL Health Findings Lab™

Manganese

A trace mineral involved in amino acid, cholesterol, and carbohydrate metabolism, and bone formation.

Evidence-Based
Fact-Checked
Updated: Oct 10, 2026
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Clinical Profile

Quick Reference

Scientific Rating
4.4
/ 5.0
Standardized Form
Manganese Bisglycinate or Manganese Sulfate

Manganese is a cofactor for several enzymes, most notably Manganese Superoxide Dismutase (MnSOD), the principal antioxidant enzyme in the mitochondria. It is vital for protecting cellular energy centers from oxidative stress generated during ATP production.

Clinical Summary

Supports bone formation and systemic antioxidant defenses.

Dosage Guidelines

1.8mg to 2.3mg daily.

Safety & Side Effects

Inhaled manganese is neurotoxic; oral toxicity is rare but can cause neurological symptoms at extreme megadoses.

Known Interactions

Iron and calcium can decrease manganese absorption.

Scientific References

Medical Disclaimer

The information provided in this clinical review is for educational and informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment.

*These statements have not been evaluated by the Food and Drug Administration (FDA). This product or ingredient is not intended to diagnose, treat, cure, or prevent any disease.

Always consult your physician or other qualified health provider with any questions you may have regarding a medical condition, or before beginning any new diet, fitness, supplement, or treatment regimen, especially if you have pre-existing medical conditions or are taking prescribed medications.

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