Quick Reference
- Scientific Rating
-
4.6/ 5.0
- Standardized Form
- Black Pepper Extract (Standardized to 95% Piperine, e.g., BioPerine)
Piperine is the pungent alkaloid in black pepper. In pharmacology, it is classified as a bioenhancer. It works primarily by inhibiting UGTs (enzymes involved in hepatic glucuronidation) and P-glycoprotein (an efflux pump in the intestines). By blocking these natural detoxification pathways, piperine prevents the liver and gut from prematurely destroying and excreting other compounds. For example, piperine increases the bioavailability of curcumin by up to 2,000%.
Table of Contents
Clinical Summary
Universally utilized in supplement formulations to force the absorption of poorly bioavailable botanical compounds (like curcumin, resveratrol, and CoQ10).
Dosage Guidelines
5mg to 20mg daily, always formulated alongside the primary active ingredient.
Safety & Side Effects
Can cause gastrointestinal irritation or acid reflux in sensitive individuals.
Known Interactions
MAJOR interaction potential: Because it alters liver enzyme function, it can dangerously increase the blood levels of numerous prescription medications (e.g., statins, blood thinners, and anticonvulsants).
Scientific References
- 1
- 2
- 3
- 4
Medical Disclaimer
The information provided in this clinical review is for educational and informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment.
*These statements have not been evaluated by the Food and Drug Administration (FDA). This product or ingredient is not intended to diagnose, treat, cure, or prevent any disease.
Always consult your physician or other qualified health provider with any questions you may have regarding a medical condition, or before beginning any new diet, fitness, supplement, or treatment regimen, especially if you have pre-existing medical conditions or are taking prescribed medications.
