Quick Reference
- Scientific Rating
-
5.0/ 5.0
- Standardized Form
- Cholecalciferol (derived from lanolin or lichen)
Vitamin D3 (Cholecalciferol) is synthesized in the skin via UVB exposure. In the liver and kidneys, it converts to its active steroid hormone form, calcitriol. It enhances intestinal calcium absorption and interacts with vitamin D receptors (VDR) on immune cells to modulate both innate and adaptive immune responses.
Table of Contents
Clinical Summary
Gold-standard nutrient for preventing osteomalacia/rickets and broadly supported for autoimmune and respiratory health.
Dosage Guidelines
1,000 IU to 5,000 IU daily, depending on serum 25(OH)D levels.
Safety & Side Effects
Hypercalcemia (elevated blood calcium) at extreme megadoses over long periods.
Known Interactions
Corticosteroids can impair Vitamin D metabolism.
Scientific References
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Medical Disclaimer
The information provided in this clinical review is for educational and informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment.
*These statements have not been evaluated by the Food and Drug Administration (FDA). This product or ingredient is not intended to diagnose, treat, cure, or prevent any disease.
Always consult your physician or other qualified health provider with any questions you may have regarding a medical condition, or before beginning any new diet, fitness, supplement, or treatment regimen, especially if you have pre-existing medical conditions or are taking prescribed medications.